IncumbentMike Rounds Republican
General election
- Julian Beaudion Democrat
former South Dakota state trooper, activist, and businessman
incumbent U.S. senator (2015–present)
- Brian Bengs Independent
U.S. Navy and Air Force veteran, former Northern State University political science professor, and Democratic nominee for U.S. Senate in 2022
Democratic primary
former South Dakota state trooper, activist, and businessman
Republican primary
- Mike Rounds Incumbent
incumbent U.S. senator (2015–present)
Navy veteran and businessman