IncumbentLindsey Graham Republican
General election
- Kasie Whitener Libertarian
educator, author, former chair of the South Carolina Libertarian Party State Committee
- Democrat Nominee TBD
- Republican Nominee TBD
Democratic primary
pediatrician and nominee for in 2022
former senior vice president of institutional advancement at Paine College and nominee for in 2004 and 2018
author and candidate for U.S. Senate in 2022 (write-in)
logistics professional
Republican primary
Duncan councilmember
hip hop artist
- Lindsey Graham Incumbent
incumbent U.S. senator (2003–present)
appliance repair executive
Horry County Republican Party executive committeeman
motivational speaker
Libertarian primary
educator, author, former chair of the South Carolina Libertarian Party State Committee
motivational speaker
Other
house painter