General election
incumbent U.S. senator
- Mark Baisley Republican
state senator from the 4th district (2023–present) (previously ran for governor)
Primaries
Democratic primary
incumbent U.S. senator
state senator from the 34th district (2019–present)
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college professor, candidate for U.S. Senate in 2022, and candidate for in 2024
Republican primary
state senator from the 4th district (2023–present) (previously ran for governor)
business owner
AI strategic advisor
former state representative from the 16th district (2011–2017) and candidate for Colorado's 8th congressional district in 2024
