IncumbentEd Markey Democrat
General election
- John Deaton Republican
attorney and nominee for U.S. Senate in 2024
- Joe Tache Independent
organizer
- Morgan Dawicki Independent
03-21 |title=Morgan G Dawicki Independent Candidate for U.S. Senate |url=https://votemgd.com/ |access-date=2025-11-05 |website=votemgd.com |language=en-US}}
- Philip Peter Devincentis Independent
Jr.
- Democrat Nominee TBD
Democratic primary
- Ed Markey Incumbent
incumbent U.S. senator (2013–present)
U.S. representative for (2015–present) and 2020 presidential candidate
professor and architect
Republican primary
attorney and nominee for U.S. Senate in 2024
Westport School Committee Chair and nominee for Massachusetts House of Representatives' 8th Bristol district in 2024