IncumbentDarrell Issa Republican
General election
- Democrat Nominee TBD
- Republican Nominee TBD
Other
- Jim Desmond Republican
(Republican), San Diego County supervisor from the 5th district (2019–present) (previously ran in the 49th district)
- Marni von Wilpert Democrat
(Democratic), San Diego city councilor from the 5th district (2020–present) (previously ran for state senate)
- Ammar Campa-Najjar Democrat
(Democratic), naval officer, runner-up for mayor of Chula Vista in 2022, and runner-up for this district in 2018 and 2020
- Corinna Contreras Democrat
(Democratic), Vista councilmember (2018–present)
- Eric Shaw Democrat
(Democratic), digital marketing executive
- Kevin Patrick O'Neil Republican
(Republican), computer software engineer
- Luis F. Reyna Independent
(No party preference), civil rights organizer
- Mike Schaefer Democrat
(Democratic), member of the California State Board of Equalization from the 4th district (2019–present) and perennial candidate
- Stephen Clemons Democrat
(Democratic), energy systems executive
