IncumbentMike DeWine Republican
General election
- Amy Acton Democrat
former director of the Ohio Department of Health (2019–2020)
- Don Kissick Libertarian
television station operator, nominee for Ohio's 5th congressional district in 2018, and nominee for U.S. Senate in 2024
- Vivek Ramaswamy Republican
founder of Roivant Sciences and candidate for president in 2024
Primaries
Democratic primary
former director of the Ohio Department of Health (2019–2020)
Republican primary
founder of Roivant Sciences and candidate for president in 2024
automotive entrepreneur
Libertarian primary
television station operator, nominee for Ohio's 5th congressional district in 2018, and nominee for U.S. Senate in 2024
(write-in)