Israel and Iran traded strikes early Monday after Iran launched missiles at Israel on Sunday, the most serious crossfire since a fragile ceasefire took effect April 8.
Israel's military said it intercepted the missiles and later said people could leave areas reinforced against missile attacks; missile sirens sounded across central and northern Israel and explosions were heard in the north after the military identified more missiles launched from the direction of Iran.
Iran's state broadcaster confirmed the launches and Iran closed parts of its airspace; Iraq's Civil Aviation Authority announced a 72-hour airspace closure, Syria's aviation authority announced a 12-hour closure, and flights from Tehran's main international airport were suspended.
Iranian state television reported explosions in Isfahan, Karaj, Tabriz and Tehran and Tehran closed the airspace around Imam Khomeini International Airport after Israeli strikes on Iranian territory.
Israel's military said it struck Iranian military targets in the western and central parts of the country, and later confirmed a strike on a petrochemical plant in Mahshahr; Iranian state media also reported damage at the Karun Mahshahr Petrochemical Company and at a military complex in Tabriz, with no casualties reported.
Iran's Revolutionary Guard warned, "Should these acts of aggression be repeated, the responses will be broader in scope and will encompass all American and Zionist targets throughout the region," referencing attacks in Lebanon and on Iran's coast and vessels around the Strait of Hormuz.
The Revolutionary Guard also said it had targeted two military bases in Israel as part of an operation it called Operation Nasr, or "Victory," and said it launched missiles after Israel targeted radar sites in three areas of Iran.
Yemen's Iran-backed Houthi rebels said they struck Israel and warned they would target Israel-affiliated ships in the Red Sea, declaring a ban on Israeli vessels navigating the route and signaling their operations would intensify in response to escalation.
Regional officials said concerted diplomatic efforts were underway to salvage the ceasefire, and officials from Egypt, Saudi Arabia, Turkey, Pakistan and Qatar urged the U.S. administration to pressure both sides; one official involved in mediation efforts said Pakistan-led mediators were furious about the Israeli strike on Beirut and said the strike was "to disrupt our efforts to reach a deal" and that "Trump has to stop Netanyahu's reckless maneuvers."
A senior U.S. official said President Donald Trump called Israeli Prime Minister Benjamin Netanyahu to urge him not to retaliate immediately and believed he had convinced Netanyahu to wait; Trump also told U.S. media he was not happy about Israel's strikes in Beirut and said he wanted Iran to stop firing missiles and return to the negotiating table.
Missile alert sirens also sounded across neighboring Jordan and in Saudi Arabia near the Al Kharj governorate, home to Prince Sultan Air Base, where Saudi state media later said the missile danger had passed; Israel's rescue services said there were no reports of casualties or impacts from a missile launch from Yemen.
U.S. Central Command posted on X that "U.S. forces across the Middle East remain vigilant and ready," and the U.S. Embassy in Israel directed employees and family members to shelter in place; the White House did not comment on Israel's strike in Beirut.
Hezbollah confirmed it attacked a group of Israeli state fighters with drones overnight and rejected the U.S.-hosted ceasefire deal, saying any overall agreement must include the situation in Lebanon.
Between March 2 and June 4, Lebanon's Ministry of Public Health said more than 3,500 people were killed and more than 10,000 wounded by Israeli strikes in Lebanon; Israel's office of Prime Minister Benjamin Netanyahu posted that the strike on Dahieh was retaliation and that Israel is "completing the elimination of the terrorist villages adjacent to our border."
An Israeli official said Prime Minister Benjamin Netanyahu was set to hold a security cabinet meeting at 11 a.m. local time to consider the exchanges.
Monday also marked the 100th day of the Iran war, which officials said began Feb. 28 when Israel and the United States killed Supreme Leader Ayatollah Ali Khamenei and other senior Iranian leaders; the war raged until a nominal ceasefire on April 8 but has been challenged by fighting around the Strait of Hormuz and between Israel and Lebanon's Hezbollah.
Iran's central military command, the Khatam Al-Anbia, announced a halt in military operations on Monday, saying it had "delivered a painful response" and that "a halt in military operations is hereby announced," while warning that "in the event of continued aggression and provocations, including in southern Lebanon, much stronger and more crushing actions will follow."
President Donald Trump wrote in a post on Truth Social that "Israel and Iran must immediately stop 'shooting'" and said both sides were seeking an "immediate CEASEFIRE," adding that "final negotiations on 'Peace' are proceeding" and that "things should move quickly," and he said "The Blockade will remain in place, and in full force and effect, until a 'Final Deal' is reached."
Trump also said he would not unfreeze Iranian assets before a ceasefire deal is reached.
The Israeli military said Monday it had detected a new barrage of missiles launched from Iran, the sixth salvo since the latest flare-up began.
Lebanon's health ministry said an Israeli air raid on Beirut's southern suburbs left two people dead and 20 more wounded.
Iran said the United States held responsibility for the resumption of fighting, with foreign ministry spokesman Esmaeil Baqaei saying, "Without a doubt ... the actions of the Zionist regime in the region cannot be separated from U.S. policies."
Iran fired drones at Israel on Sunday after Israel struck Beirut's southern suburbs, and the tit-for-tat exchanges between the two countries continued into Monday.
Iran's Islamic Revolution Guard Corps told state media the latest ballistic missile launches had ended and called the operation a "complete success," but warned that operations would resume if Israel restarted attacks on Lebanon, which has been a condition of the ceasefire.
President Donald Trump said he would ask Israeli Prime Minister Benjamin Netanyahu not to retaliate and warned Netanyahu that he "won't have any choice...I call all the shots," saying Netanyahu would have to accept any deal the United States negotiates.