IncumbentDarline Graham Republican
General election
- Annie Andrews Democrat
pediatrician and nominee for in 2022
- Kasie Whitener Libertarian
former chair of the South Carolina Libertarian Party State Committee
- Lindsey Graham Republican
incumbent U.S. Senator (died July 11, 2026)
Independents:
Democratic primary
pediatrician and nominee for in 2022
former senior vice president of institutional advancement at Paine College and nominee for in 2004 and 2018
Also on the ballot:
Republican primary
incumbent U.S. Senator (died July 11, 2026)
appliance repair executive
Also on the ballot:
Thomas Dismukes 5.2%- Pat Herrmann 3.8%
- Calvin Cowen 3.0%
- Darius L. Mitchell 2.3%
- Patrick Herrmann